Nobel Prize in Physiology & Medicine 2013:
|James E. Rothman, Thomas C.Sudhof, Randy W.Schekman|
The Nobel Prize in Physiology or Medicine 2013 was awarded jointly to James E. Rothman( American), Randy W. Schekman ( American) and Thomas C. Südhof (German Born researcher) "for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells".
These three Winners,solved the mystery of how the cell organizes its transport system. Each cell is a factory that produces and exports molecules. These molecules are transported around the cell in small packages called vesicles.
Randy Schekman discovered a set of genes that were required for vesicle traffic. James Rothman unravelled protein machinery that allows vesicles to fuse with their targets to permit transfer of cargo. Thomas Südhof revealed how signals instruct vesicles to release their cargo with precision.